Other medical conditions
are typically the cause of EPI

The two most common conditions that lead to Exocrine Pancreatic Insufficiency (EPI) are:


Chronic pancreatitis (CP) is the leading cause of EPI. It is progressive and is often diagnosed later in adulthood (typically between 30-40 years of age). As many as 8 in 10 adults with CP develop EPI.11,12,16


Cystic fibrosis (CF) is an inherited disease that affects approximately 30,000 people in the United States. Approximately 66% of CF patients develop EPI shortly after birth. This number jumps to 85% by one year of age.11,15,17

Other conditions that may be associated with EPI include:12

  • Irritable Bowel Syndrome (IBS)
  • Crohn’s disease
  • Ulcerative colitis
  • Celiac disease
  • Type 1 and 2 Diabetes

It’s important to share your complete medical history with your doctor when asking about your symptoms.

Download free resources from the Talking with Your Doctor About EPI section. These materials can help make the conversation easier.