The PANCREAZE® Engage Program
You may pay as little as $0*

VIVUS is committed to helping ensure access to PANCREAZE®.

  • Commercial co-pay assistance: pay as little as $0*
  • Patients who are paying out-of-pocket for the full cost of their medication can save up to $200 on their PANCREAZE prescription.**
  • Monthly discounts on products to support eligible EPI patients with their nutritional needs on a 24/7 online storefront.
  • Patient Assistance Program provides PANCREAZE® at no cost for eligible patients unable to pay for their prescriptions. Download application form (PDF).

Educational resources


*Eligible patients may pay as little as $0 on their co-pay for their PANCREAZE® prescription with a maximum benefit of up to $100 per prescription fill (30-day supply) per month.

**Patients may be eligible for this offer if they are not insured and are responsible for the cost of their prescriptions. Eligible patients may save up to $200 off out-of-pocket costs for a 30-day supply of PANCREAZE (pancrelipase) capsules. Savings will vary depending on the dose of PANCREAZE that your doctor prescribes for you. Patients taking the 16,800 or 21,000 lipase unit doses will save up to $200 on a 30-day supply every month and patients taking the 2,600, 4,200 or 10,500 lipase unit doses will save up to $67 on a 30-day supply every month.

VIVUS provides eligible Pancreaze patients or caregivers of eligible patients under the age of 18, a monthly discount. Eligible patients or caregivers of eligible patients will be issued single-use claim codes on a monthly basis that can be redeemed and applied to the purchase of products available in the VIVUS Health Store. VIVUS reserves the right to expire these claim codes at any time, delete or modify the amount of the benefit, and change the products offered in its store. By registering for the PANCREAZE Engage program, and by using this site, you are authorizing VIVUS or its designee to contact you by telephone, direct mail or email in order to receive the benefits and verify continued eligibility. VIVUS reserves the right to revoke eligibility and access to these monthly codes based upon proof of prescription and/or PANCREAZE use.

The patient does not have insurance or their medication is not covered
  • Please note, some patients with Medicare Prescription Drug Coverage (Part D) who cannot afford their medication and who meet certain financial criteria may also be eligible for assistance
    • In order to qualify for the program, the patient must spend 4% or more of their gross annual income on prescription drugs
  • The patient’s income level is equal to or less than 300% above the U.S. Federal Poverty Guidelines
  • The patient lives in the United States or a U.S. Territory
  • The patient is being treated for EPI by a U.S. licensed healthcare provider as an outpatient
What is the most important information I should know about PANCREAZE®?​

PANCREAZE® may increase your chance of having a serious, rare bowel disorder called fibrosing colonopathy that may require surgery. The risk of having this condition may be reduced by following the dosing instructions that your healthcare provider gave you.

Take PANCREAZE® exactly as prescribed by your doctor. Do not take more or less PANCREAZE® than directed by your doctor.

Call your doctor right away if you have any unusual or severe stomach area (abdominal) pain, bloating, trouble passing stool (having bowel movements), nausea, vomiting, or diarrhea.

What should I tell my doctor before taking PANCREAZE®?

Tell your doctor if you:

  • are allergic to pork (pig) products
  • have a history of blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy)
  • have gout, kidney disease, or high blood uric acid (hyperuricemia)
  • have trouble swallowing capsules
  • have any other medical condition
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

What are the possible side effects of PANCREAZE®?
PANCREAZE® may cause serious side effects, including:
  • A rare bowel disorder called fibrosing colonopathy.
  • Irritation of the inside of your mouth. This can happen if PANCREAZE® is not swallowed completely.
  • Increase in blood uric acid levels. This may cause worsening of swollen, painful joints (gout) caused by an increase in your blood uric acid levels.
  • Allergic reactions including trouble with breathing, skin rashes, or swollen lips.

The most common side effects include pain in your stomach (abdominal pain) and gas.

These are not all the side effects of PANCREAZE®. Talk to your doctor about any side effect that bothers you or does not go away. You may report side effects to the FDA at 1-800-FDA-1088 or You may also report side effects to VIVUS, Inc. at 1-888-998-4887.

How do I take PANCREAZE®?
  • Do not crush or chew the PANCREAZE® capsules or their contents, and do not hold the capsule or contents in your mouth. Take PANCREAZE® exactly as your doctor tells you. Read the Medication Guide for directions on how to give PANCREAZE® to adults and children (children older than 12 months).
  • Read the Medication Guide for directions on how to give PANCREAZE® to infants (children up to 12 months).
Please read the PANCREAZE® Medication Guide and PANCREAZE® Product Information and discuss any questions you have with your doctor.